Leyao Yu

How are we able to recall a word we want to say? This basic ability, called word retrieval, is often compromised in patients with brain damage. Interestingly, many patients who can name words they see, like identifying a pet in the room as a “cat”, struggle with retrieving words in everyday discourse.

Scientists have long sought to understand how the brain retrieves words during speech. A new study by researchers at New York University sheds light on this mystery, revealing a left-lateralized network in the dorsolateral prefrontal cortex that plays a crucial role in naming. The findings, published in Cell Reports, provide new insights into the neural architecture of language, offering potential applications for both neuroscience and clinical interventions.

Mapping the Brain’s Naming Network

Word retrieval is a fundamental aspect of human communication, allowing us to link concepts to language. Despite decades of research, the exact neural dynamics underlying this process — particularly in natural auditory contexts — remain poorly understood.

NYU researchers — led by Biomedical Engineering Graduate Student Leyao Yu and Associate Professor of Biomedical Engineering at NYU Tandon and Neurology at NYU Grossman School of Medicine Adeen Flinker — recorded electrocorticographic (ECoG) data from 48 neurosurgical patients to examine the spatial and temporal organization of language processing in the brain. By using unsupervised clustering techniques, the researchers identified two distinct but overlapping networks responsible for word retrieval. The first, a semantic processing network, was located in the middle and inferior frontal gyri. This network was engaged in integrating meaning and was sensitive to how surprising a word was within a given sentence. The second, an articulatory planning network, was situated in the inferior frontal and precentral gyri, which played a crucial role in speech production, regardless of whether words were presented visually or auditorily.

Auditory Naming and the Prefrontal Cortex

The study builds upon decades of work in language neuroscience. Previous research suggested that different regions of the brain were responsible for retrieving words depending on whether they were seen or heard. However, earlier studies relied on methods with limited temporal resolution, leaving many unanswered questions about how these networks interact in real time.

By leveraging the high spatial and temporal resolution of ECoG, the researchers uncovered a striking ventral-dorsal gradient in the prefrontal cortex. They found that while articulatory planning was localized ventrally, semantic processing was uniquely represented in a dorsal region of the inferior frontal gyrus and middle frontal gyrus — a previously underappreciated hub for language processing.

"These findings suggest that a missing piece in our understanding of language processing lies in this dorsal prefrontal region," explains lead author Leyao Yu. "Our study provides the first direct evidence that this area is involved in mapping sounds to meaning in an auditory context."

Implications for Neuroscience and Medicine

The study has far-reaching implications, not only for theoretical neuroscience but also for clinical applications. Language deficits, such as anomia — the inability to retrieve words — are common in stroke, brain injury, and neurodegenerative disorders. Understanding the precise neural networks involved in word retrieval could lead to better diagnostics and targeted rehabilitation therapies for patients suffering from these conditions.

Additionally, the study provides a roadmap for future research in brain-computer interfaces (BCIs) and neuroprosthetics. By decoding the neural signals associated with naming, scientists could potentially develop assistive devices for individuals with speech impairments, allowing them to communicate more effectively through direct brain-computer communication.

For now, one thing is clear: our ability to name the world around us is not just a simple act of recall, but the result of a sophisticated and finely tuned neural system — one that is now being revealed in greater detail than ever before.

Yu, L., Dugan, P., Doyle, W., Devinsky, O., Friedman, D., & Flinker, A. (2025). A left-lateralized dorsolateral prefrontal network for naming. Cell Reports, 44(5), 115677. https://doi.org/10.1016/j.celrep.2025.115677